Bonding tissues and cross-linking proteins with...

A - Human Necessities – 61 – K

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Details

A61K 47/48 (2006.01) A61P 9/14 (2006.01) A61P 17/00 (2006.01) A61P 17/16 (2006.01)

Patent

CA 2586320

Naphthalimide compounds are used in tissue bonding and protein cross~linking applications. When activated by an activating agent, such as light in the 400 - 500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide~labeled chitosan, is also capable of bonding tissues without subsequent direct illumination , of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.

On utilise des composés de naphthalimide dans des applications de liaison de tissus et de réticulation de protéines. Lorsque les composés de naphthalimide sont activés par un facteur d'activation tel que la lumière dans une gamme d'absorption de 400 - 500 nm, les composés de naphthalimide forment des espèces chimiquement réactives qui réticulent les protéines, lient entre eux les tissus conjonctifs et lient entre eux les tissus et d'autres biomatériaux. Une biomolécule étiquetée au naphthalimide telle que le chitosane étiqueté au naphthalimide est également capable de lier les tissus sans éclairage direct subséquent, de la zone des tissus en contact. Les composés de naphthalimide peuvent s'utiliser dans la réparation des tissus ou des artères, la stabilisation d'une paroi artérielle après l'angioplastie, dans des agents pharmaceutiques d'attache destinés aux surfaces de tissus pour assurer l'administration locale de médicaments, ainsi que pour lier chimiquement à la peau des produits des soins de la peau, des filtres solaires et des produits cosmétiques.

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