C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61P 19/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12Q 1/42 (2006.01) C12Q 1/48 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2463925
The present invention relates to polypeptides that bind to RANK and comprise amino acid sequences of RANKL external surface loops. The invention also relates to fragments, analogs, and derivatives of such polypeptides. The present invention further relates to compositions comprising the polypeptides described herein. Also included are methods for inhibiting osteoclast differentiation, methods for inhibiting bone resorption, and methods for competitively inhibiting RANKL activity. The invention also provides methods for treating diseases or conditions which are at least partially characterized by loss of bone mass.
Cette invention concerne des polypeptides qui se lient à RANK et qui comprennent des séquences d'acides aminés de boucles de surface extérieure RANKL. Cette invention concerne également des fragments, des analogues et des dérivés de ces polypeptides. En outre, cette invention concerne des compositions renfermant ces polypeptides, ainsi que des méthodes permettant d'inhiber la différenciation ostéoclastique, des méthodes permettant d'inhiber la résorption osseuse ainsi que des méthodes permettant d'inhiber de manière compétitive l'activité RANKL. Cette invention concerne également des méthodes de traitement de maladies ou d'états se caractérisant au moins en partie par une perte de masse osseuse.
Lam Jonathan
Ross F. Patrick
Teitelbaum Steven L.
Barnes-Jewish Hospital
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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