Bone augmentation utilizing muscle-derived progenitor...

A - Human Necessities – 61 – K

Patent

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Details

A61K 35/34 (2006.01) A61K 35/12 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2722758

The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non- soft tissue (e.g. bone). Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.

La présente invention concerne des cellules progénitrices dérivées des muscles présentant une survie à long terme suite à une transplantation dans des tissus corporels et pouvant augmenter les tissus non mous suite à leur introduction (par exemple, via injection, transplantation ou implantation) dans un site de tissus non mous (par exemple des os). L'invention concerne également des méthodes d'isolement des cellules progénitrices dérivées des muscles et des méthodes de modification génétique des cellules pour une thérapie de transfert de gènes. L'invention concerne également des méthodes d'utilisation des compositions contenant des cellules progénitrices dérivées des muscles pour augmenter et renforcer des tissus osseux de mammifères, y compris d'humains, dans le traitement de divers états pathologiques fonctionnels, y compris l'ostéoporose, la maladie de Paget, l'ostéogenèse imperfecta, une fracture osseuse, l'ostéomalacie, la réduction de la résistance trabéculaire osseuse, la réduction de la résistance corticale osseuse et la réduction de la densité osseuse chez les patients âgés.

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