Bone cement with antimicrobial peptides

Details Bone cement with antimicrobial peptides Bone cement with antimicrobial peptides

A - Human Necessities

61

K

A61K 38/10 (2006.01) A61F 2/28 (2006.01) A61K 38/17 (2006.01) A61K 47/02 (2006.01) A61L 27/22 (2006.01) A61L 27/54 (2006.01) A61P 31/04 (2006.01) A61P 31/06 (2006.01) A61L 27/12 (2006.01)

Patent

CA 2336030

The invention relates to bone material for the prevention and treatment of osteomyelitis, which material is provided with antimicrobial peptides (AMPs) consisting of an amino acid chain which contains a domain of 10 to 25 amino acids, wherein the majority of the amino acids of the one half of the domain are positively charged amino acids and the majority of the amino acids of the other half of the domain are uncharged amino acids, which AMPs can be released to the surrounding area for a period of time and wherein the bone material forms bone cement after curing and the AMPs are distributed homogeneously in the cured bone cement. The invention further relates to a method of manufacturing the bone material, wherein the bone material is cured to bone cement and wherein the AMPs are distributed homogeneously in the cured bone cement.

L'invention concerne un matériau à base d'os, destiné à la prévention et au traitement de l'ostéomyélite, ce matériau contenant des peptides antimicrobiens composés d'une chaîne d'acides aminés possédant un domaine de 10 à 25 acides aminés, la majorité des acides aminés d'une moitié du domaine étant des acides aminés à charge positive et la majorité des acides aminés de l'autre moitié du domaine étant des acides aminés non chargés. Ces peptides antimicrobiens peuvent être libérés dans la zone environnante pendant une certaine période, le matériau à base d'os formant un ciment osseux après durcissement et les peptides antimicrobiens étant répartis de manière homogène dans le ciment osseux durci. L'invention concerne encore un procédé de fabrication de ce matériau à base d'os, consistant à durcir ce matériau pour obtenir du ciment osseux, dans lequel les peptides antimicrobiens sont répartis de manière homogène.

Affiliated with

Also associated with

Rating

Bone cement with antimicrobial peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bone cement with antimicrobial peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bone cement with antimicrobial peptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2068566