Bone grafts with reduced protease activity and methods of...

Details Bone grafts with reduced protease activity and methods of... Bone grafts with reduced protease activity and methods of...

C - Chemistry, Metallurgy

12

Q

C12Q 1/37 (2006.01) A61F 2/28 (2006.01) A61K 35/32 (2006.01) A61K 38/18 (2006.01) A61L 27/38 (2006.01)

Patent

CA 2747508

The invention features bone grafts (such as bone allografts) with reduced protease activity. These bone grafts are useful, for example, in conjunction with a polypeptide of interest (such as platelet derived growth factor) for treating, stabilizing, preventing, and/or delaying a bone, periodontium, ligament, cartilage, or tendon condition in an individual (such as a human). Additionally, the invention provides methods of measuring the protease activity associated with a bone graft, reducing the level of protease activity associated with a bone graft, selecting a bone graft with an acceptable level of protease activity, and methods of administering a bone graft and a polypeptide of interest to an individual.

Linvention concerne des greffes osseuses (telles que des allogreffes osseuses) qui présentent une activité protéase réduite. Ces greffes osseuses sont utiles, par exemple conjointement avec un polypeptide dintérêt (tel quun facteur de croissance dérivé des plaquettes) dans le traitement, la stabilisation, la prévention et/ou le retardement dune affection osseuse, parodontale, ligamentaire, cartilagineuse ou tendineuse chez un sujet (tel qu'un humain). Par ailleurs, linvention concerne des procédés de mesure de lactivité protéase associée à une greffe, de réduction du niveau de lactivité protéase associée à une greffe osseuse, de sélection dune greffe osseuse présentant un niveau acceptable dactivité protéase, et des procédés dadministration dune greffe osseuse et dun polypeptide dintérêt à un sujet.

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