Bone mass anabolic composition comprising olpadronate

Details Bone mass anabolic composition comprising olpadronate Bone mass anabolic composition comprising olpadronate

A - Human Necessities

61

K

A61K 31/66 (2006.01) A61K 33/06 (2006.01) A61K 33/16 (2006.01) C07F 9/09 (2006.01)

Patent

CA 2208714

The present invention provides methods for bone mass anabolic preservation or augmentation in human or other animal subjects affected by osteoporosis or other metabolic bone disorder characterized by systemic or regional bone loss, using bisphosphonates formula- tions, wherein the bone mass anabolic composition contains effective non-toxic doses of [3-(N,N-dimethylamine)-1-hydroxypropylidene]- bisphosphonic acid or olpadronate or the monosodium or other pharmaceutically acceptable salt thereof.

L'invention concerne des procédés de conservation et d'augmentation de la masse osseuse, agissant sur l'anabolisme de sujets humains ou animaux atteints d'ostéoporose ou d'autres troubles métaboliques des os caractérisés par une diminution de la masse osseuse systémique ou régionale. Ces procédés utilisent des formulations de diphosphonates, dans lesquelles la composition à action anabolique sur la masse osseuse contient des doses efficaces non toxiques d'acide diphosphonique de [3-(N,N-diméthylamine)-1-hydroxypropylidène] ou olpadronate, ou de son sel monosodique ou autres sels pharmaceutiquement acceptables.

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