Bone morphogenetic protein-16 (bmp-16) compositions

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/18 (2006.01) C07K 14/495 (2006.01) C07K 14/51 (2006.01) C07K 16/22 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2265508

Purified BMP-16 proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-16 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.

L'invention concerne des protéines-16 morphogénétiques osseuses (BMP-16) purifiées et des procédés pour les fabriquer. L'invention concerne également des molécules d'ADN codant lesdites protéines BMP-16. Lesdites protéines peuvent être utilisées dans le traitement de défauts et de troubles affectant l'os, le cartilage ou d'autres tissus conjonctifs, dont les tendons, les ligaments et le ménisque, pour la cicatrisation et la répartition des tissus connexes et pour traiter des troubles et des défauts affectant d'autres tissus, tels que l'épiderme, les nerfs, les muscles, dont le muscle cardiaque, et d'autres tissus et blessures, ainsi que des organes tels que les tissus du foie, du poumon, du coeur, du pancréas et du rein. Lesdites protéines peuvent également servir à induire la croissance et/ou la différentiation de cellules embryonnaires ou souches non différentiées.

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