C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) C07K 14/51 (2006.01) C07K 16/18 (2006.01) C12N 15/12 (2006.01) C12N 15/18 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2313381
Purified BMP-17 and BMP-18 proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-17 and BMP-18 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, epithelium, brain, spleen, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.
L'invention concerne des protéines BMP-17 et BMP-18 purifiées ainsi que des procédés relatifs à leur élaboration. L'invention concerne également des molécules d'ADN codant lesdites protéines. On peut utiliser ces protéines pour le traitement d'anomalies et de troubles des os, du cartilage et autres tissus connectifs (tendons, ligaments et ménisques inclus), en liaison avec le traitement des plaies et autres réparations de tissu. On peut encore utiliser lesdites protéines pour le traitement d'anomalies et de troubles des tissus englobant l'épiderme, les nerfs, les muscles (muscle cardiaque inclus), ainsi que pour le traitement d'autres tissus, blessures et organes (tissu du foie, des poumons, de l'épithélium, du cerveau, de la rate, du coeur, du pancréas et des reins). Enfin, ces protéines peuvent être utiles pour induire la croissance et/ou la différenciation de cellules embryonnaires et souches non différenciées.
Celeste Anthony J.
Murray Beth L.
Genetics Institute Llc
Genetics Institute Inc.
Gowling Lafleur Henderson Llp
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