Bone morphogenetic protein (bmp)-17 and bmp-18 and compositions

Details Bone morphogenetic protein (bmp)-17 and bmp-18 and compositions Bone morphogenetic protein (bmp)-17 and bmp-18 and compositions

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 14/51 (2006.01) C07K 16/22 (2006.01) C07K 19/00 (2006.01) C12N 15/18 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2574929

Purified BMP-17 and BMP-18 proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-17 and BMP-18 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, epithelium, brain, spleen, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.

L'invention porte sur les protéines BMP-17 et BMP-18 purifiées et des procédés permettant de les produire. Les molécules d'ADN codant les protéines BMP-17 et BMP-18 sont aussi divulguées. Les protéines peuvent servir au traitement de défauts et de troubles des os, du cartilage, et d'autres tissus conjonctifs, y compris les tendons, les ligaments et les ménisques, à la guérison des plaies et aux réparations tissulaires apparentées, de même qu'au traitement des affections et des anomalies des tissus, notamment l'épiderme, les nerfs, les muscles, y compris le muscle cardiaque, et d'autres tissus et plaies, et des organes comme le foie, les poumons, l'épithélium, le cerveau, la rate, le cour, le pancréas et les reins. Les protéines peuvent aussi être utiles pour induire la croissance et/ou la différentiation des cellules embryonnaires et souches non différenciées.

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