Bone morphogenetic protein (bmp)-binding domains of proteins...

Details Bone morphogenetic protein (bmp)-binding domains of proteins... Bone morphogenetic protein (bmp)-binding domains of proteins...

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2690974

The present invention relates to the identification and use of bone morphogenetic protein (BMP)-binding domains of members of the repulsive guidance molecule (RGM) protein family, and polypeptide fragments and fusion proteins derived therefrom. The domains, i.e., peptide fragments and fusion proteins, according to the invention are suitable as agents for the active or passive immunization of individuals, or as diagnostic and therapeutic agents for use for diseases or medical conditions in whose origin or progression a member of the RGM family and a cellular receptor associated with this molecule, such as neogenin and/or BMP in particular, is involved. The invention further relates to monoclonal and polyclonal antibodies directed against the binding domains according to the invention, and against the polypeptides derived therefrom, and to methods for producing the polypeptides, fusion proteins, and antibodies according to the invention.

Identification et utilisation de domaines de liaison de la protéine morphogénétique de l'os (BMP) dans le cas d'éléments de la famille protéique des molécules de guidage répulsif (RGM), et fragments polypeptidiques et protéines de fusion dérivés de ces domaines. Lesdits domaines de l'invention - fragments peptidiques et des protéines de fusion - conviennent comme agents pour l'immunisation active ou passive d'individus, ou bien comme agents diagnostiques et thérapeutiques dans le cas de maladies et d'états pathologiques dans l'origine ou dans la progression desquels est impliqué un membre de la famille RGM et un récepteur cellulaire associé à cette molécule, tels qu'une néogénine et/ou une BMP en particulier. L'invention concerne également des anticorps monoclonaux et polyclonaux dirigés contre les domaines de liaison selon l'invention, et contre les polypeptides qui en sont dérivés, ainsi que des méthodes permettant de produire les polypeptides, protéines de fusion et anticorps de l'invention.

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