Bone morphogenetic protein formulations

Details Bone morphogenetic protein formulations Bone morphogenetic protein formulations

A - Human Necessities

61

K

A61K 38/18 (2006.01)

Patent

CA 2612332

Protein formulations that can be lyophilized and are stable in organic solvents. The formulations contain bone morphogenetic proteins, lyoprotectants, and oxidation/reduction stabilizers. Optionally, the formulations may also contain solvent environment stabilizers. The protein formulations can be incorporated into a polymeric matrix to make medical devices for delivering the protein, and coatings for medical devices.

La présente invention concerne des formulations de protéines lyophilisables et stables dans des solvants organiques. Ces formulation contiennent des de protéines de morphogenèse osseuse, des lyoprotecteurs, et des stabilisants d'oxydoréduction. Ces formulations peuvent éventuellement également contenir des stabilisants d'environnement du solvant. Ces formulations de protéines peuvent s'incorporer à une matrice polymère pour confectionner des dispositifs médicaux d'administration de protéines, et des revêtements pour dispositifs médicaux.

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