C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/10 (2006.01) A61K 38/18 (2006.01) A61P 19/00 (2006.01) C07K 7/08 (2006.01) C07K 14/46 (2006.01) C07K 14/51 (2006.01)
Patent
CA 2706882
A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all ostcogenic activity of rhBMP- 2, increases the rate at which rhBMP-2 induces bone formation, and BBP in- duces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diag- nostic and clinical applications requiring calcification and ostcogcnesis.
L'invention propose un peptide cyclisé appelé peptide de liaison à BMP (BBP) qui est un peptide synthétique qui se lie avidement à un rhBMP-2, comme le font les formes endogènes de BBP, et une conservation de séquence entre espèces conduit à une diversité de compositions de BBP utiles. Le BBP augmente l'activité ostéogénique globale du rhBMP-2, augmente la vitesse à laquelle le rhBMP-2 induit la formation du tissu osseux, et le BBP n'induit que la calcification. L'invention porte sur des compositions et des substrats comprenant le BBP, et sur des procédés consistant à utiliser le BBP, qui s'utilisent dans des applications thérapeutiques, de diagnostic et cliniques nécessitant la calcification et l'ostéogenèse.
Behnam Keyvan
Murray Elsa J.
Murray Samuel S.
Wang Jeffrey C.
Ridout & Maybee Llp
The Regents Of The University Of California
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