Bone-pathobolism treating agent

Details Bone-pathobolism treating agent Bone-pathobolism treating agent

A - Human Necessities

61

K

A61K 38/19 (2006.01) A61K 38/17 (2006.01) A61K 47/36 (2006.01) A61P 3/00 (2006.01) A61P 19/08 (2006.01) C07K 14/52 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2347107

Novel remedies for bone metabolic errors. These remedies comprise at least one member selected from the group consisting of osteoclastogenesis inhibitory factor (OCIF), analogs thereof and variants thereof and polysaccharides or derivatives thereof. As the polysaccharides or derivatives thereof, use may be made of heparin, dextran sulfate, etc. These remedies have excellent therapeutic effects on bone metabolic errors such as osteoporosis, hypercalcemia and rheumatoid arthritis and can sustain the activities over a long time, which makes them highly useful as drugs.

L'invention concerne de nouveaux agents thérapeutiques permettant de traiter les déformations osseuses. Ces agents thérapeutiques comprennent au moins un élément sélectionné dans le groupe constitué d'un facteur inhibiteur d'ostéoclastogenèse (OCIF), ses analogues, ses variantes, ses polysaccharides ou ses dérivés. Les polysaccharides ou dérivés précités peuvent être l'héparine, le dextran-sulfate, etc. Ces agents thérapeutiques agissent de manière efficace sur les déformations osseuses telles que l'ostéoporose, l'hypercalcémie et la polyarthrite rhumatoïde et leur action est durable, ce qui en fait des médicaments très prisés.

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