Bone/polyurethane composites and methods thereof

Details Bone/polyurethane composites and methods thereof Bone/polyurethane composites and methods thereof

A - Human Necessities

61

L

A61L 27/36 (2006.01) A61L 27/44 (2006.01) A61L 27/56 (2006.01)

Patent

CA 2745038

Present inventions present composites of bone particles and polyurethane(s), as well as methods of making such composite and uses thereof. A porous composite comprises a plurality of bone particles; and polyurethanes with which the bone particles are combined. To prepare a porous composite, a composition comprise a plurality of bone particles, polyurethane precursors including polyisocyanate prepolymers and polyols, water and catalyst. A composition is either naturally moldable and/or injectable, or it can be made moldable and/or injectable. After implantation or injection, a composition may be set to form a porous composite that provides mechanical strength and supports the in-growth of cells. Inventive composites have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength for most orthopedic applications.

La présente invention concerne des composites de particules osseuses et de polyuréthane(s), leurs procédés de fabrication et leurs utilisations. Ces composites poreux comprennent une pluralité de particules osseuses combinées à des polyuréthanes. Ils sont préparés à partir d'une composition comprenant une pluralité de particules osseuses, des précurseurs de polyuréthanes comprenant des prépolymères de polyisocyanate et des polyols, de l'eau et un catalyseur. Ces compositions sont naturellement ou peuvent être rendues moulables et/ou injectables. Après implantation ou injection, les compositions peuvent être durcies pour former des composites poreux qui apportent une résistance mécanique et favorisent la multiplication interne de cellules. Les composites de l'invention ont l'avantage de pouvoir remplir un site d'implantation de forme irrégulière tout en étant durcissables pour apporter la résistance mécanique nécessaire à la plupart des applications orthopédiques.

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