Bone precursor cells: compositions and methods

Details Bone precursor cells: compositions and methods Bone precursor cells: compositions and methods

C - Chemistry, Metallurgy

12

N

C12N 5/078 (2010.01) C12N 5/077 (2010.01) C12N 5/02 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2200197

Disclosed are compositions of bone precursor cells and methods for their preparation and use. Bone precursor cells are cells which are not hematopoietic and which can differentiate into osteoblasts upon exposure to a bone growth factor and deposit calcium into the extracellular matrix. Such bone precursor cells are useful in the treatment of certain bone related disorders and diseases, such as osteoporosis, or in promoting fracture repair. In addition, methods of differentiating bone precursor cells into osteoblasts, and other diagnostic and even prognostic methods are provided.

Compositions de cellules osseuses précurseurs et méthodes d'élaboration et d'utilisation de ces compositions. Les cellules osseuses précurseurs sont des cellules qui ne sont pas hématopoïétiques et qui peuvent se différencier en ostéoblastes par exposition à un facteur de croissance osseuse et déposer du calcium dans une matrice extracellulaire. Des telles cellules osseuses précurseurs sont utiles pour le traitement de certaines maladies de type osseux, comme l'ostéoporose, ou pour faciliter la réparation d'une fracture. L'invention porte en outre sur des méthodes de différentiation de cellules osseuses précurseurs en ostéoblastes et sur d'autres méthodes de diagnostic et même de pronostic.

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