Bone regeneration in osteoporosis using human bone marrow...

A - Human Necessities – 61 – K

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A61K 35/28 (2006.01) C12N 5/0775 (2010.01) A61K 35/32 (2006.01)

Patent

CA 2278539

The method of osteoporosis treatment and infusion compositions of the invention increase the number of the patient's own progenitor cells (hMSCs) and the reservoir of available bone-forming osteoblasts. They can be used to generate cortical and cancellous bone which has been lost as a result of post- menopausal osteoporosis, male idiopathic osteoporosis, congenital osteoporosis and other bone resorption diseases. Most cases of osteoporosis can be treated with a metered intravenous infusion of the composition of the invention over the course of 15-30 minutes, using customary cell reinfusion therapy techniques.

Le procédé de traitement de l'ostéoporose et les compositions de perfusion de cette invention ont pour effet d'augmenter le nombre de cellules souches (hMSC) du patient et la réserve d'ostéoblastes disponibles formant la matière osseuse. On peut les utiliser pour produire de l'os cortical et de l'os spongieux qui a été perdu suite à une ostéoporose post-ménopausique, une ostéoporose idiopathique masculine, une ostéoporose congénitale et d'autres maladies de résorption osseuse. On peut traiter la plupart des cas d'ostéoporose au moyen d'une perfusion intraveineuse dosée de la composition de cette invention sur une période de 15-30 minutes à l'aide de techniques thérapeutiques classiques de réinjection de cellules.

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