C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) A61K 39/395 (2006.01) C07H 21/00 (2006.01) C12N 9/16 (2006.01) C12N 15/62 (2006.01) C12P 21/08 (2006.01) C12Q 1/44 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2104995
Abstract of the Disclosure A bone-related protein named OSF-8 which is obtained from bone tissue of a mammal including mouse or human, and a process for its production. This protein is a novel naturally occurring mammal protein which belongs to a group of sulfatases. OSF-8 degrades the sulfate groups of the sugar chains of proteoglycan, which makes up the cartilage matrix, during the replacement of cartilage into bone tissue at the stage of osteogenesis. OSF-8 can be used as an agent for treating bone metabolic diseases, and its high organ specificity for bones enables its use as a diagnostic reagent for bone metabolic diseases.
Amann Egon
Ito Toshimi
Otawara-Hamamoto Yoko
Takeshita Sunao
Bereskin & Parr
Hoechst Japan Limited
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