Boron-containing compounds, uses and preparation thereof

C - Chemistry – Metallurgy – 07 – F

Patent

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C07F 5/04 (2006.01) A61K 31/69 (2006.01) A61P 29/00 (2006.01) C02F 1/50 (2006.01) C07F 5/02 (2006.01)

Patent

CA 2721320

There are provided compounds of formulae (I) and (II), and homo- and hetero-dimers and t.pi.mers thereof R1 is -OH, a C1-C12 alkyl, a C2-C12 alkenyl, a C2-C12 alkynyl, a C3-C8 cycloalkyl, a C3-C8 cycloalkenyl, a C6-C12 aryl, or a C1- C12heteroaryl group The compounds are prepared by reaction of glycerol and a boronic acid, or boricor metaboric-acid. Such compounds are useful for treating inflammation and/or pan. In particular, the compounds may be used to accelerate the healing of wounds and/or bums. The compounds are also useful for water treatment, by preventing the presence of bacteria and/or algae, and by reducing the turbidity of water.

L'invention porte sur des composés des formules (I) et (II), et sur des homo- et hétéro-dimères et -trimères de ceux-ci. R1 représente -OH, un alkyle en C1-C12, un alcényle en C2-C12, un alcynyle en C2-C12, un cycloalkyle en C3-C8, un cycloalcényle en C3-C8, un aryle en C6-C12 ou un groupe hétéroaryle en C1-C12. Les composés sont préparés par réaction de glycérol et d'un acide boronique, ou de l'acide borique ou métaborique. De tels composés sont utiles pour le traitement de l'inflammation et/ou de la douleur. En particulier, les composés peuvent être utilisés pour accélérer la guérison de lésions et/ou de brûlures. Les composés sont également utiles pour le traitement de l'eau, en empêchant la présence de bactéries et/ou d'algues et en réduisant le trouble de l'eau.

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