C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
260/500.1, 260/4
C07F 9/38 (2006.01) A61K 41/00 (2006.01) A61K 51/04 (2006.01) C07F 9/6596 (2006.01)
Patent
CA 1219595
BORON CONTAINING POLYPHOSPHONATES FOR THE TREATMENT OF CALCIFIC TUMORS James J. Benedict Abstract Boron containing polyphosphonates of the formula Image ; or Image ;or Image ; or Image ; wherein Z is a boron-containing radical; R2 is an alkyl group containing from 1 to about 10 carbon atoms; R3 is a geminal, diphosphonate or a vicinal polyphosphonate containing up to 10 phosphonic acid radicals; R4 is hydrogen, lower alkyl, amino, benzyl, halogen, hydroxyl, - CH2COOH, - CH2PO3H2, or - CH2CH2PO3H2; and the salts and esters thereof, have high affinity for calcified tissues, in particular calcific tumors. The compounds are useful in boron neutron capture therapy of such tumors.
406199
Gowling Lafleur Henderson Llp
The Procter & Gamble Company
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