Boron steroid mimics and pharmaceutical compositions

Details Boron steroid mimics and pharmaceutical compositions Boron steroid mimics and pharmaceutical compositions

C - Chemistry, Metallurgy

07

F

C07F 5/02 (2006.01) A61K 31/69 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2361064

Boron heterocycle steroid mimics are provided that are useful as pharmaceutical agents, particularly in the treatment of estrogen-dependent disorders such as estrogen-dependent cancers. The compounds are also useful in diagnostic techniques such as magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS), in boron neutron capture therapy, and in fluorescence emission-based modalities. Pharmaceutical formulations and methods of using the novel compounds are provided as well.

L'invention concerne des substances mimétiques de stéroïdes d'hétérocycle au bore, utiles comme agents pharmaceutiques, particulièrement pour le traitement de troubles liés aux oestrogènes (par exemple, cancers dépendant des oestrogènes). Les substances considérées sont également utiles dans les techniques de diagnostic du type imagerie par résonance magnétique et spectroscopie par résonance magnétique, dans le cadre de la thérapie à capture de bore, et dans les opérations à base d'émission par fluorescence. L'invention concerne en outre des formulations et des procédés faisant appel aux substances décrites.

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