Boronic acid and ester inhibitors of thrombin

C - Chemistry – Metallurgy – 07 – F

Patent

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Details

C07F 5/02 (2006.01) A61K 31/69 (2006.01) A61K 31/695 (2006.01) C07F 7/10 (2006.01) C07F 9/38 (2006.01)

Patent

CA 2208971

Novel boronic acid and ester and carboxyl-modified amino acid compounds of formula (I): R1-Z-CHR1-A, which are inhibitors of trypsin-like enzymes, are disclosed, where R1, Z, R2 and A are defined within.

La présente invention porte sur de nouveaux composés d'acide boré, d'ester et d'acide aminique modifié par carboxyle, inhibiteurs d'enzymes de type trypsine, faisant partie de la formule (I): R?1¿-Z-CHR?2¿-A, formule dans laquelle R?1¿, Z, R?2¿ et A sont définis dans la présente invention.

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