Boropeptide inhibitors of thrombin which contain a...

C - Chemistry – Metallurgy – 07 – F

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C07F 5/02 (2006.01) A61K 31/395 (2006.01) A61K 31/675 (2006.01) A61K 31/69 (2006.01) A61K 38/05 (2006.01) C07D 207/16 (2006.01) C07D 207/26 (2006.01) C07D 403/00 (2006.01) C07D 405/00 (2006.01) C07F 9/572 (2006.01) C07K 5/06 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2174311

This invention relates to the discovery of novel and useful .alpha.-amino acid analogs, and the pharmaceutically acceptable salts and prodrugs thereof, containing a disubstituted pyrrolidine ring conjugated to an .alpha.-amino acid, useful as inhibitors of thrombin.

L'invention concerne la découverte de nouveaux analogues d'.alpha.-aminoacide, ainsi que leurs sels et promédicaments acceptables pharmaceutiquement, contenant un noyau de pyrrolidine disubstitué conjugué à un .alpha.-aminoacide, qui sont efficaces en tant qu'inhibiteurs de la thrombine.

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