Boroproline compound combination therapy

Details Boroproline compound combination therapy Boroproline compound combination therapy

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/69 (2006.01) A61K 38/04 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) A61K 38/17 (2006.01) A61K 38/21 (2006.01) A61K 39/00 (2006.01) A61K 45/06 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2491474

A method id provided for treating subjects with combination therapy including compounds of Formula I. It was surprisingly discovered that this combination enhanced the efficacy of both agents, and that administration of Formula I compounds induced cytokine and chemokine production in vivo. The combinations can be used to enhanced ADCC, stimulate immune responses and /or patient and treat certain disorders. The invention also relates to kits and compositions relating to such combinations.

Cette invention se rapporte à un procédé servant à traiter des sujets au moyen d'une polythérapie utilisant des composés représentés par la formule (I). On a découvert de façon surprenante que cette polythérapie améliore l'efficacité des deux agents, et que l'administration de composés de formule (I) induit la production de cytokine et de chimiokine in vivo. Ces polythérapies peuvent être utilisées pour améliorer la cytotoxicité médiée par des cellules dépendant des anticorps (ADCC), pour stimuler les réactions immunitaires et/ou l'organisme du patient et pour traiter certains troubles. Cette invention concerne également des kits et des compositions associées à ces polythérapies.

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