Borrelidin-producing polyketide synthase and its uses

Details Borrelidin-producing polyketide synthase and its uses Borrelidin-producing polyketide synthase and its uses

C - Chemistry, Metallurgy

07

D

C07D 313/00 (2006.01) A61K 31/365 (2006.01) A61P 17/06 (2006.01) A61P 33/06 (2006.01) A61P 35/00 (2006.01) C12N 15/52 (2006.01) C12P 17/08 (2006.01)

Patent

CA 2506669

The present invention relates to the biosynthesis of polyketides and derives from the cloning of nucleic acids encoding a polyketide synthase and other associated proteins involved in the synthesis of the polyketide borrelidin. Materials and methods including enzyme systems, nucleic acids, vectors and cells are provided for the preparation of polyketides including borrelidin and analogues and derivatives thereof. Novel polyketide molecules are also provided.

La présente invention se rapporte à la biosynthèse de polykétides et leurs dérivés provenant du clonage d'acides nucléiques codant une polykétide synthase et d'autres protéines associées impliquées dans la synthèse de la polykétide borrélidine. Des substances et des procédés renfermant des systèmes enzymatiques, des acides nucléiques, des vecteurs et des cellules servent à la préparation de polykétides contenant une borrélidine ainsi que ses analogues et dérivés. Font également l'objet de cette invention de nouvelles molécules de polykétides.

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