Botulinum neurotoxin a receptor and the use thereof

Details Botulinum neurotoxin a receptor and the use thereof Botulinum neurotoxin a receptor and the use thereof

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 38/16 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 39/00 (2006.01) C07K 14/33 (2006.01) C07K 16/28 (2006.01) C12N 15/12 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01) G01N 33/68 (2006.01) C12N 9/52 (2006.01)

Patent

CA 2625972

The present invention is based on the identification of synaptic vessel glycoprotein SV2 as the BoNT/A receptor and the further identification of various BoNT/A-binding fragments of SV2. The disclosure here provides new tools for diagnosing and treating botulism.

La présente invention porte sur l'identification de la glycoprotéine de la vésicule synaptique SV2 servant de récepteur de BoNT/A ainsi que sur l'identification de divers fragments de liaison de SV2 avec BoNT/A. L'invention porte également sur de nouveaux outils de diagnostic et de traitement du botulisme.

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