Botulinum toxin polypeptides and their use as vaccine...

Details Botulinum toxin polypeptides and their use as vaccine... Botulinum toxin polypeptides and their use as vaccine...

C - Chemistry, Metallurgy

07

K

C07K 14/33 (2006.01) A61K 39/08 (2006.01) A61K 39/39 (2006.01) C07K 7/08 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2158748

A short polypeptide, typically in the range 7-35 amino acid residues, that contains a Botulinum toxin T cell epitope and is useful for administration to a mammal as part of a vaccination therapy. Following administration of the polypeptide, an individual has an enhanced response to known botulinum toxin vaccines, such as toxoid vaccine; thus the effects of the vaccine can be improved and increased. Polypeptide formulations and vaccination methods are described.

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