Bovine leptin protein, antisense and antibody

Details Bovine leptin protein, antisense and antibody Bovine leptin protein, antisense and antibody

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) C07H 21/00 (2006.01) C07K 14/575 (2006.01) C07K 16/26 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2457805

A bovine adipocyte-specific polypeptide, termed leptin, is expressed in the fat tisse of cattle. Expression may be altered in over fat cattle, or expression may be in the form of a protein of lesser biological activity relative to that of leaner cattle. The bovine adipocyte polypeptide, DNA and RNA molecules encoding therefor, methods for its preparation, and antibodies specific for the polypeptide are disclosed. Methods of limiting fat deposition include administering leptin or leptin DNA, and methods of altering intake include administering leptin, leptin DNA, or an antibody directed against leptin.

La présente invention concerne un polypeptide spécifique de l'adipocyte bovin, appelé leptine, exprimé dans le tissu adipeux de bétail. L'expression peut être modifiée dans du bétail présentant un excès de graisse, ou l'expression peut se présenter sous la forme d'une protéine à activité biologique inférieure par rapport à du bétail plus maigre. L'invention concerne le polypeptide d'adipocyte bovin, les molécules d'ADN et d'ARN codant pour ledit polypeptide, ses procédés de préparation, et des anticorps spécifiques aux polypeptides. L'invention concerne en outre des procédés permettant la limitation de dépôt de graisse comprenant l'administration de leptine, d'ADN de leptine, ou un anticorps dirigé contre la leptine.

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