Bovine pancreatic trypsin inhibitor derived inhibitors of...

Details Bovine pancreatic trypsin inhibitor derived inhibitors of... Bovine pancreatic trypsin inhibitor derived inhibitors of...

C - Chemistry, Metallurgy

12

N

C12N 15/15 (2006.01) A61K 38/57 (2006.01) C07K 14/81 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 15/70 (2006.01) C12N 15/81 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2145517

Compounds derived from BPTI which inhibit factor VIIa-TF complex with an inhibition constant of less than 500 nM, their pharmaceutical compositions, and methods of use. Also disclosed are isolated nucleic acid segments encoding for the com- pounds, vectors comprising the nucleic acid segment and promoter, transformed host cells, and a method for preparing the com- pounds using transformed host cells.

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