C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/04 (2006.01) A61K 39/12 (2006.01) C07K 14/18 (2006.01) C07K 16/10 (2006.01) C12N 15/86 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2744750
The present invention relates to chimeric pestiviruses having utility as immunogenic compositions and vaccines wherein said chimeric pestivirus comprises a bovine viral diarrhea virus which does not express its homologous Ems protein, further wherein said chimeric pestivirus expresses a heterologous Ems protein derived from another pestivirus, or a natural, synthetic or genetic variant of said heterologous Erns protein. Also described herein are methods and kits for treating or preventing the spread of bovine viral diarrhea virus infection, as well as methods and kits for differentiating between vaccinated and wild-type infected animals.
La présente invention concerne des pestivirus chimériques ayant une utilité en tant que compositions et vaccins immunogènes où ledit pestivirus chimérique comprend un virus de diarrhée virale bovine qui nexprime pas sa protéine Ems homologue, où ledit pestivirus chimérique exprime une protéine Ems hétérologue dérivée dun autre pestivirus, ou un variant naturel, synthétique ou génétique de ladite protéine Erns hétérologue. La présente invention concerne en outre des procédés et des kits pour traiter ou prévenir la propagation de linfection par le virus de la diarrhée virale bovine, ainsi que des procédés et des kits pour différencier des animaux vaccinés et infectés par le type sauvage.
Ankenbauer Robert Gerard
Luo Yugang
Welch Siao-Kun Wan
Yuan Ying
Pfizer Inc.
Torys Llp
LandOfFree
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