Brachyspira hyodysenteriae vaccine

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

IPC codes

C12N 15/31 (2006.01) A61K 39/02 (2006.01) A61K 39/40 (2006.01) A61K 48/00 (2006.01) C07K 14/20 (2006.01) C12N 1/21 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Type

Patent

Patent number

CA 2492716

Description

The present invention relates to nucleic acid sequences encoding a 61 kD and a 20 kD Brachyspira hyodysenteriae lipoprotein and to parts of such nucleic acid sequences that encode an immunogenic fragment of such lipoproteins, and to DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof. The invention also relates to a 61 kD and a 20 kD Brachyspira hyodysenteriae lipoprotein and immunogenic parts thereof encoded by such sequences. Furthermore, the present invention relates to vaccines comprising such nucleic acid sequences and parts thereof, DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof, lipoproteins or immunogenic parts thereof and antibodies against such lipoproteins or immunogenic parts thereof. Also, the invention relates to the use of said lipoproteins in vaccines and for the manufacture of vaccines. Moreover, the invention relates to the use of said nucleic acid sequences, lipoproteins or antibodies for diagnostic or vaccination purposes. Finally the invention relates to diagnostic kits comprising such a nucleic acid, lipoprotein or antibodies against such lipoprotein.

L'invention concerne : des séquences d'acide nucléique codant pour des lipoprotéines de Brachyspira hyodysenteriae 61 kD et 20 kD et des parties de ces séquences d'acide nucléique qui codent pour un fragment immunogène de ces lipoprotéines ainsi que des fragments d'ADN, des molécules d'ADN recombinées, des supports recombinés vivants et des cellules hôtes comprenant ces séquences d'acide nucléique ou ces parties de séquences d'acide nucléique ; des lipoprotéines de Brachyspira hyodysenteriae 61 kD et 20 kD et des parties immunogènes de ces lipoprotéines codées par ces séquences ; des vaccins comprenant ces séquences d'acide nucléique et des parties de ces séquences, des fragments d'ADN, des molécules d'ADN recombinées, des supports recombinés vivants et des cellules hôtes comprenant ces séquences d'acide nucléique ou ces parties de séquences d'acide nucléique, des lipoprotéines ou des parties immunogènes de ces lipoprotéines et des anticorps dirigés contre ces lipoprotéines ou leurs parties immunogènes ; l'utilisation de ces lipoprotéines dans des vaccins et dans la fabrication de vaccins ; l'utilisation de ces séquences d'acide nucléique, lipoprotéines ou anticorps à des fins de diagnostic ou de vaccination ; enfin, des trousses diagnostiques comprenant ces acides nucléiques, ces lipoprotéines ou ces anticorps dirigés contre ces lipoprotéines.

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