C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 4/12 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2678404
It is disclosed herein that Brachyury is expressed in human tumors, specifically in tumors of the small intestine, stomach, kidney, bladder, uterus, ovary, and testes, as well as in lung, colon and prostate carcinomas. Immunogenic Brachyury polypeptides are disclosed herein. These polypeptides can be used in diagnostic assays for Brachyury expression, as well as for inducing an immune response to Brachyury. Polynucleotides encoding the immunogenic Brachyury polypeptides, vectors including these polypeptides, host cells transformed with these vectors, and methods of using these polypeptides, polynucleotides, vectors, and host cells are provided. Methods of diagnosing a Brachyury-expressing cancer are also provided. Exemplary cancers include small lung, colon, intestine, stomach, kidney, bladder, uterus, ovary, and testes and prostate cancers. Methods of treating cancer are also disclosed.
L'invention concerne des polypeptides Brachyury immunogènes. Brachyury est exprimé dans les tumeurs humaines, notamment dans les tumeurs de l'intestin grêle, de l'estomac, des reins, de la vessie, de l'utérus, des ovaires et des testicules, ainsi que dans les carcinomes des poumons, du colon et de la prostate. Les polypeptides Brachyury immunogènes peuvent être utilisés dans des dosages diagnostics de l'expression de Brachyury, ainsi que pour induire une réponse immunitaire à Brachyury. L'invention concerne également des polynucléotides codant pour les polypeptides Brachyury immunogènes, des vecteurs comprenant ces polypeptides, des cellules hôtes transformées avec ces vecteurs et des procédés d'utilisation de ces polypeptides, polynucléotides, vecteurs et cellules hôtes. L'invention concerne également des procédés de diagnostic d'un cancer exprimant Brachyury. Comme exemples de cancers, on peut citer les cancers de l'intestin grêle, de l'estomac, des reins, de la vessie, de l'utérus, des ovaires, des testicules et de la prostate. L'invention concerne également des procédés de traitement du cancer.
Kozlov Andrei P.
Palena Claudia M.
Schlom Jeffrey
Smart & Biggar
The Government Of The United States Of America As Represented By
LandOfFree
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