Bradykinin analogs containing a non-peptide bond

Details Bradykinin analogs containing a non-peptide bond Bradykinin analogs containing a non-peptide bond

C - Chemistry, Metallurgy

07

K

530/7.18, 167/10

C07K 7/18 (2006.01) C07K 7/02 (2006.01) C07K 14/575 (2006.01) C07K 14/685 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1335622

The invention provides a linear peptide which is an analog of bradykinin having a binding site responsible for the affinity of the peptide to a receptor on a target cell. The analog having a reduced isostere linkage instead of a peptide bond between an amino acid of the binding site and an adjacent amino acid, so that the analog is capable of acting as a competitive inhibitor of the endogenous peptide by binding to the receptor.

594845

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