Bradykinin antagonist peptides

Details Bradykinin antagonist peptides Bradykinin antagonist peptides

C - Chemistry, Metallurgy

07

K

530/7.18

C07K 7/18 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01)

Patent

CA 1292842

ABSTRACT The substitution or the L-Pro at the 7-position of the peptide hormone, bradykinin or other substituted analogs of bradykinin with an aromatic amino acid or the D-configuration converts bradykinin amino into a bradykinin antagonist. The invention further includes additional modifications at other positions within the novel 7-position modified bradykinin antagonists which increase enzyme resistance, antagonist potency and/or specificity of the new bradykinin antagonists. The analogs produced are useful in treating conditions and diseases of the mammal and human body in which an excess of bradykinin or related kinins are produced or injected as by bites into the body.

511734

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