Bradykinin antagonist peptides

Details Bradykinin antagonist peptides Bradykinin antagonist peptides

C - Chemistry, Metallurgy

07

K

C07K 7/18 (2006.01) A61K 38/08 (2006.01) C07D 207/12 (2006.01) C07D 207/16 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2106762

Novel compounds according to aspects of this invention are provided by the modification of the sequence of the mammalian peptide hormone bradykinin (Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg) by the substitution of the L-Pro at position 7 in a unique manner which produces sequence-related analogues, i.e., hydroxyproline ethers or thioethers, that act as specific and competitive inhibitors of the biological activities of bradykinin to convert bradykinin agonists into bradykinin antagonists. Pharmaceutically-acceptable salts thereof, and compositions containing them are also provided. These compounds are useful in the treatment of various diseases including inflammatory disorders, asthma, septic shock and burn pain, for example, where an excess of bradykinin or related kinins are produced or injected, e.g., by insect bites.

Affiliated with

Also associated with

Rating

Bradykinin antagonist peptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Bradykinin antagonist peptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Bradykinin antagonist peptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1935940