Bradykinin antagonists

Details Bradykinin antagonists Bradykinin antagonists

A - Human Necessities

61

K

A61K 31/00 (2006.01) A61K 31/4184 (2006.01) A61K 31/437 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61K 31/496 (2006.01) A61K 31/498 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 39/44 (2006.01) A61K 51/00 (2006.01) A61P 1/04 (2006.01) A61P 9/02 (2006.01) A61P 11/06 (2006.01) A61P 19/02 (2006.01) A61P 25/04 (2006.01) A61P 27/16 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07D 211/90 (2006.01) C07D 215/24 (2006.0

Patent

CA 2319730

Disclosed are multibinding compounds which are bradykinin antagonists. The multibinding compounds of this invention contain from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a bradykinin antagonist. The multibinding compounds of this invention are useful in the treatment and prevention of diseases such as cancer, pain, shock, asthma, rhinitis, arthritis, inflammatory bowel disease, and the like.

L'invention concerne de nouveaux composés à liaisons multiples qui sont des antagonistes de bradykinine. Ces composés à liaisons multiples comprennent 2 à 10 ligands, fixés par covalence à un ou plusieurs segments de liaison, chacun de ces ligands étant, indépendamment des autres, un antagoniste de bradykinine. Les composés à liaisons multiples de cette invention sont utiles pour prévenir et traiter les maladies comme le cancer, l'algie, l'état de choc, l'asthme, la rhinite, l'arthrite, l'affection intestinale inflammatoire, et analogues.

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