G - Physics
01
N
G01N 33/574 (2006.01)
Patent
CA 2706453
The present invention provides, inter alia, methods for predicting the sensitivity of a disease, such as cancer, to an ERK1 or ERK2 or MEK inhibitor by detecting the presence of an allele of BRAF in cells mediating the disease. Methods of treatment are also provided.
La présente invention concerne, entre autres, des méthodes de prédiction de la sensibilité d'une maladie, telle que le cancer, à un inhibiteur de ERK1 ou ERK2 ou de MEK. Ces méthodes permettent de détecter la présence d'un allèle de BRAF dans des cellules médiant la maladie. L'invention concerne également des méthodes de traitement.
Carr Donna Marie
de Lorenzo Marc M.
Hosted Thomas J.
Samatar Ahmed A.
Simon Jason S.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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