C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/15 (2006.01) A61K 38/57 (2006.01) C07K 14/81 (2006.01) C07K 16/38 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01)
Patent
CA 2268007
The present invention relates to a novel BAIT protein which is a member of serpin superfamily which is expressed primarily in brain tissue. In particular, isolated nucleic acid molecules are provided encoding the human BAIT protein. BAIT polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of BAIT activity. Also provided are diagnostic methods for detecting nervous system- related disorders and therapeutic methods for treating nervous system-related disorders.
L'invention concerne une nouvelle protéine de l'inhibiteur cérébro-associé de l'activateur du plasminogène de type tissulaire (BAIT), laquelle est un membre de la superfamille des serpines, qui s'exprime généralement dans le tissu du cerveau. L'invention concerne notamment des molécules d'acides nucléiques isolées codant la protéine humaine BAIT. On décrit également des polypeptides BAIT en tant que vecteurs et cellules hôtes, ainsi que des procédés de recombinaison aux fins de production de ceux-ci. L'invention concerne encore des procédés de criblage destinés à l'identification des agonistes et antagonistes de l'activité de BAIT, des procédés de diagnostic destinés à détecter des troubles associés au système nerveux, de même que des procédés thérapeutiques destinés au traitement de troubles associés au système nerveux.
Coleman Timothy A.
Dillon Patrick J.
Hastings Gregg A.
Lawrence Daniel A.
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
The American National Red Cross
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