C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 489/08 (2006.01) A61K 31/485 (2006.01) C07D 489/00 (2006.01)
Patent
CA 2144770
The present invention relates to a novel brain cell protective agent having for its active ingredient a morphinan derivative represented with Compound 1 (see figure I) or pharmacologically acceptable acid addition salt thereof. The compounds used in the present invention were found to have excellent defensive effects against brain nerve cell necrosis in both in vitro and in vivo pharmacological evaluations, and can be used as useful preventive and therapeutic agents of ischemic brain disorders, brain nerve cell disorders and dementia.
Nouvel agent de protection de cellules cérébrales renfermant, à titre d'ingrédient actif, un dérivé de morphinane représenté par le composé de la formule (1), ou son sel pharmaceutiquement acceptable d'addition d'acide. Ce composé présente un excellent effet de protection contre la nécrose des cellules nerveuses crâniennes dans les tests pharmacologiques in vitro et in vivo, et peut donc s'utiliser dans la prévention ou le traitement de l'encéphalopathie ischémique, des troubles des cellules nerveuses crâniennes, et de la démence.
Endo Takashi
Imamura Yoshifumi
Matsuda Susumu
Miyauchi Yasushi
Nagase Hiroshi
Mcfadden Fincham
Toray Industries Inc.
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