Brain imaging radiopharmaceuticals

Details Brain imaging radiopharmaceuticals Brain imaging radiopharmaceuticals

C - Chemistry, Metallurgy

07

F

260/428.1, 260/5

C07F 13/00 (2006.01) A61K 51/04 (2006.01)

Patent

CA 1225996

BRAIN IMAGING RADIOPHARMACEUTICALS ABSTRACT OF THE DISCLOSURE A compound of the structure: Image wherein each R' is independently a hydrogen atom, an alkyl group or X, and at least one of the groups R' is X, m is 0 or 1, Z is the anion of a strong mineral acid, b is an integer of 2 or greater and X has the formula: Image where R" and R''' are independently hydrogen atoms or alkyl groups, Ar is an aromatic group, and a, d and n are integers. The compounds are usefully converted to technetium-99m complexes. The technetium-99m complexes are useful in brain perfusion imaging.

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