Brain specific binding members

Details Brain specific binding members Brain specific binding members

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 39/395 (2006.01) C12N 15/13 (2006.01) G01N 33/50 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2393292

The present invention relates to specific binding members directed to the brain, including specific binding members able to pass through the blood brain barrier or which are directed to areas of brain inflammation or blood brain barrier breakdown. Panels and mixtures of antibodies are provided, also individual antibody molecules and VH and VL domains, along with methods of obtaining specific binding members by selection, e.g. using libraries displayed on the surface of filamentous bacteriophage.

L'invention concerne des éléments de liaisons spécifiques dirigés vers le cerveau comprenant des éléments de liaisons spécifiques capables de passer la barrière hémato-encéphalique, ou qui sont dirigés vers des zones à affection cérébrale de caractère inflammatoire ou de rupture de la barrière hémato-encéphalique. L'invention concerne aussi des listes et des mélanges d'anticorps, des molécules d'anticorps individuel et des domaines VH et VL, ainsi que des procédés d'obtention d'éléments de liaisons spécifiques par sélection, c'est à dire par l'utilisation de bibliothèques présentées sur la surface du bactériophage filamenteux.

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