C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/100, 260/110
C07D 211/90 (2006.01) C07D 209/32 (2006.01) C07D 213/80 (2006.01) C07D 213/82 (2006.01) C07D 401/12 (2006.01) C07J 43/00 (2006.01) C07K 14/70 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1327566
ABSTRACT OF THE DISCLOSURE The invention provides quaternary salts having the formula [D-QC]+ (II) wherein [D] is a centrally acting drug species and [QC]+ is the hydrophilic, ionic pyridinium salt form of a dihydropyridine ? pyridinium salt redox carrier. The subject compounds are chemical intermediates to the corresponding compounds of the formula [D-DHC] (I) wherein [D] is defined as above and [DHC] is the reduced, biooxidizable, blood-brain barrier pene- trating, lipoidal form of a dihydropyridine ? pyri- dinium salt redox carrier. The compounds of formula (I) are adapted for the site-specific/sustained delivery of centrally acting drug species to the brain.
590673
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
University Of Florida
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