C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/20 (2006.01) A61K 31/438 (2006.01) A61P 25/06 (2006.01)
Patent
CA 2727243
The present invention is directed to novel branched 3- and 6-substituted quinoline derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
La présente invention concerne de nouveaux dérivés de quinoléine 3- et 6-substituée ramifiée qui sont des antagonistes de récepteurs CGRP et utiles dans le traitement ou la prévention de maladies dans lesquelles CGRP est impliqué, telles que la migraine. Linvention concerne en outre des compositions pharmaceutiques comprenant ces composés et lutilisation de ces composés et compositions dans la prévention ou le traitement de maladies dans lesquelles CGRP est impliqué.
Kim June J.
Schirripa Kathy M.
Wood Michael R.
Merck Sharp & Dohme Corp.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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