Branched alkoxy-substituted 2-aminopyridines

Details Branched alkoxy-substituted 2-aminopyridines Branched alkoxy-substituted 2-aminopyridines

C - Chemistry, Metallurgy

07

D

C07D 213/73 (2006.01) A61K 31/44 (2006.01) C07D 401/10 (2006.01)

Patent

CA 2302436

The present invention relates to 6-phenyl-pyridin-2-ylamine derivatives of formula (I) wherein R1, R2, R3 and R4 are defined as in the specification, that exhibit activity as nitric oxide synthase (NOS) inhibitors, to pharmaceutical compositions containing them and to their use in the treatment and prevention of central nervous system and other disorders.

Cette invention se rapporte à des dérivés de 6-phényl-pyridin-2-ylamine, représentés par la formule (I), où R?1¿, R?2¿, R?3¿ et R?4¿ sont définis dans les pièces descriptives de l'invention, et possédant une action d'inhibition de l'oxyde nitrique synthase (NOS), à des compositions pharmaceutiques contenant ces dérivés et à leur utilisation dans le traitement et la prévention des troubles du système nerveux central et autres.

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