Branched cationic lipids for nucleic acids delivery system

Details Branched cationic lipids for nucleic acids delivery system Branched cationic lipids for nucleic acids delivery system

C - Chemistry, Metallurgy

07

J

C07J 41/00 (2006.01) A61K 9/14 (2006.01) A61K 47/28 (2006.01) C07J 51/00 (2006.01) C12N 15/87 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2742689

The present invention is directed to cationic lipid for the delivery of oligonucleotides and methods of modulating an expression of a targeted gene using the nanoparticle compositions. In particular, the invention relates to cholesterol and its derivatives having multiple positively charged moieties via branching spacers, and nanoparticle compositions of oligonucleotides encapsulated in a mixture of a cationic lipid, a fusogenic lipid and a PEG lipid.

L'invention concerne des lipides cationiques utilisés pour l'administration d'oligonucléotides et sur des méthodes de modulation de l'expression d'un gène ciblé dans lesquelles on utilise des compositions de nanoparticules. L'invention concerne en particulier le cholestérol et ses dérivés qui comportent de multiples fragments chargés positivement par l'intermédiaire d'espaceurs de ramification, et des compositions de nanoparticules d'oligonucléotides encapsulées dans un mélange formé d'un lipide cationique, d'un lipide fusogène et d'un lipide de PEG.

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