Branched-chain amino acid composition for improving skeletal...

A - Human Necessities – 61 – K

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A61K 36/19 (2006.01) A23L 1/30 (2006.01) A23L 1/305 (2006.01) A61K 31/198 (2006.01) A61K 31/205 (2006.01) A61P 21/06 (2006.01)

Patent

CA 2687107

The present invention relates to compositions and methods for improving skeletal muscle protein metabolism through encouraging skeletal muscle protein synthesis, reducing skeletal muscle protein degradation, and attenuating inflammatory signalling in exercising muscle. The compositions of the present invention comprise branched-chain amino acids, a plant extract that attenuates NF-.kappa.B activity and .gamma.-butyrobetaine, and optionally, ethyl pyruvate or diferuloylmethane.

La présente invention concerne des compositions et des procédés pour améliorer le métabolisme des protéines du muscle squelettique par stimulation de la synthèse des protéines du muscle squelettique, réduction de la dégradation des protéines du muscle squelettique et atténuation de la transmission des signaux inflammatoires dans le muscle en exercice. Les compositions de la présente invention renferment des acides aminés à chaîne ramifiée, un extrait végétal qui atténue l'activité du NF-KB et de la .gamma.-butyrobétaïne, et éventuellement du pyruvate d'éthyle et du diféruloylméthane.

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