C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/00 (2006.01) C07C 311/49 (2006.01) C07D 209/08 (2006.01) C07D 209/30 (2006.01) C07D 209/88 (2006.01) C07D 215/48 (2006.01) C07D 215/50 (2006.01) C07D 307/79 (2006.01) C07D 307/84 (2006.01) C07D 307/91 (2006.01) C07D 307/92 (2006.01)
Patent
CA 2416136
The invention relates to BCAT inhibitors and use thereof for treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the overstimulation of the excitatory amino acids, treating anxiety, psychosis, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headache, chronic pain, neuropathic pain, Parkinson's disease, diabetic retinopathy, glaucoma, CMV retinitis, urinary incontinence, opioid tolerance or withdrawal, and inducing anesthesia, as well as for enhancing cognition.
L'invention concerne des inhibiteurs BCAT et leur utilisation pour le traitement ou la prévention de déperdition neuronale associée à des attaques, ischémies, traumatismes CNS, hypoglycémies, chirurgie, ainsi que pour le traitement de maladies neurodégénératives, telles que maladies d'Alzheimer, sclérose latérale amyotrophique, maladie d'Huntington et syndrome de Down, traitement ou prévention des conséquences indésirables de la sur-stimulation des aminoacides excitateurs, traitement de l'anxiété, psychose, convulsions, perte d'audition provoquée par des antibiotiques aminoglycosides, migraines, douleurs chroniques, douleurs névropathiques, maladie de Parkinson, rétinopathie diabétique, glaucome, rétinite CMV, incontinence urinaire, tolérance ou suppression opioïde, y compris anesthésie, ainsi que pour la stimulation de la cognition.
Bora Keenan Martin
Hu Lain-Yen
Kesten Suzanne Ross
Lei Huangshu
Moreland David Winslow
Smart & Biggar
Warner-Lambert Company
Warner-Lambert Company Llc
LandOfFree
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