C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
260/31
C07J 1/00 (2006.01)
Patent
CA 1095895
ABSTRACT OF THE DISCLOSURE There are disclosed branched chain and cycloaliphatic esters of steroids having the formula: Image or the 50?II analog thereof, where R i s II or CH3; R1 is II or CH; R2 is II or CH3; R3 is II, OH, CH3 or CL; R4 is II or C1 to C4 alkyl; R5 is II, C1 to C4 alkyl or CF3, R6 is II, C1 to C4 alkyl, C1 to C4 alkoxy, halogen or .beta.-OH provi- ding that when R6 is .beta.-OH, the steroid also contains 9?-F and further providing that R1, R2, R3, R4, R5 and R6 represent at least 4 and at most 5 hydrogen atoms, except in the case of a.DELTA.1,4 steroid, in which case R1, R2, R3, R4, R% and R6 are all hydrogen; R7 is H or CH3; R8 is Image providing the R8 is -OH or Image when the steroid has an aromatic ring A and the 3-position is substituted by Image ; R9 is Image where n is 0, 1 or 2; R10 is C1 to C10 alkyl; R11 is II or C1 to C10 alkyl; R12 is an alophatic group with 1 to 18 carbon atoms, or R10 and R12 taken together with the carbon atom to which they are attached form a C7 to C12 cycloaliphatic group providing the total carbon atom content in the carboxylic acid residue is 8 to 20; ring A is either saturated or has one of the following types of unsaturation: .DELTA.1; .DELTA.4; .DELTA.1,4; .DELTA.5(10); .DELTA.1,3,5(10), and X is =O, -OH or Image providing that X is OH or Image when the steroid has an aromatic ring A. The steroid esters have andro- genic, anabolic, oestrogenic or anti-oestrogenic properties de- pending upon the ring configurations and the substituent(s). Pharmaceutical. compositions containing the steroid esters are also disclosed; as well as process for preparing the esters.
291885
Akzona Incorporated
Swabey Ogilvy Renault
LandOfFree
Branched chain and cycloaliphatic esters of the androstane... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Branched chain and cycloaliphatic esters of the androstane..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Branched chain and cycloaliphatic esters of the androstane... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-620212