Branched hydrazone linkers

C - Chemistry – Metallurgy – 07 – H

Patent

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Details

C07H 15/26 (2006.01) A61K 47/48 (2006.01) C07D 207/452 (2006.01) C07H 15/252 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2239183

Branched hydrazone linkers for linking a targeting ligand such as an antibody to a therapeutically active drug. The point of branching is at a polyvalent atom and the number of drugs increases by a factor of two for each generation of branching. A preferred drug is doxorubicin.

Segments de liaison hydrazone ramifiés destinés à lier un ligand de ciblage tel qu'un anticorps à un médicament thérapeutiquement actif. Le point de ramification se trouve au niveau d'un atome polyvalent et le nombre de médicaments augmente à raison d'un facteur deux pour chaque génération de ramification. La doxorubicine est un médicament préféré.

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