Branched molecular scaffolds for linking polymer residues to...

Details Branched molecular scaffolds for linking polymer residues to... Branched molecular scaffolds for linking polymer residues to...

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2545805

Branched molecular scaffolds are provided which are capable of linking two polymer residues (derived, for example, from polyethylene glycol) to two, three or four residues derived from biologically active molecules (e.g. from whole antibodies or from functionally active fragments or derivatives thereof), the latter being attached to the scaffold by means of hydrolytically stable linkages.

L'invention concerne des échafaudages moléculaires ramifiés, capables de lier deux résidus polymères (dérivés, par exemple, de polyéthylène glycol), à deux, trois ou quatre résidus dérivés de molécules biologiquement actives (par ex., d'anticorps entiers, ou de fragments ou dérivés fonctionnellement actifs de ces anticorps), ces dernières étant fixées à l'échafaudage par des liaisons stables au niveau hydrolytique.

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