Branched oligonucleotides as pathogen-inhibitory agents

Details Branched oligonucleotides as pathogen-inhibitory agents Branched oligonucleotides as pathogen-inhibitory agents

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2190998

Novel antisense oligonucleotides are disclosed. The present oligonucleotides have increased resistance to nuclease attack and manifest increased efficacy in combating pathogenic infections. The present oligonucleotides comprise two or more identical or different sequences, each complementary to a nucleic acid sequence of a pathogen that is essential to the pathogen's metabolism and/or reproduction. The sequences may be complementary to the same or different target nucleic acid sequence within a single pathogen, to target sequences on different strains of the same pathogen, or to target sequences on different pathogens. In the preferred embodiment, the sequences are coupled via a 3'-3' linkage, which greatly reduces 3' nucleolytic degradation.

La présente invention concerne de nouveaux oligonucléotides antisens présentant une résistance accrue à l'agression des nucléases et faisant preuve d'une efficacité accrue contre les infections pathogènes. Ces oligonucléotides comportent au moins deux séquences identiques ou différentes, toutes complémentaires d'une séquence d'acide nucléique essentielle au métabolisme et/ou à la reproduction de l'agent pathogène. Les séquences peuvent être complémentaires de séquences identiques ou différentes d'acide nucléique cible d'un même agent pathogène, complémentaires de séquences cibles de différentes souches d'un même agent pathogène, ou complémentaires de séquences cibles de différents agents pathogènes. Dans une réalisation préférée, les séquences sont couplées au niveau d'une liaison en 3'-3', réduisant ainsi fortement la dégradation nucléolytique en 3'.

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